Neurodevelopmental disorders encompass a wide range of conditions with a genetic component from ADHD to aspects of autism. Following large-scale genome sequencing projects, 125 genes have been identified that are associated with this category of disorder. Common processes affected by these genes can be determined by GO-term analysis. But to make the analysis more stringent, filters can be applied.
First, housekeeping genes, which by definition are expressed in all cell types, are removed from the list and then genes that are common to the NDD and ExAC lists can be selected. The ExAC list is a list of genes whose sequence is highly conserved over more than 60 000 human genome sequences suggesting that they have a highly significant function.